The Cubbington Pear Tree, believed to be 250 years old, has been shortlisted by the Woodland Trust and is pitted against nine other trees from across England.
Standing at the top of a hill near South Cubbington Wood, it is thought to be the largest wild pear tree in Warwickshire and the second largest in the United Kingdom.
The tree sits on the proposed phase 1 route of the HS2 line from London to Birmingham and could be lost if or when construction gets underway.
Beccy Speight, chief executive of the Woodland Trust, said: “This contest reminds us how trees have been an integral part of this country’s history and play an important role in our lives today.
“We still need better protection for individual trees across the UK and we hope everyone who votes will also support our campaign to create a register for all our Trees of National Special Interest.”
The Woodland Trust said the UK is home to one of the largest populations of ancient and veteran trees in Europe. It added that over 13,000 people had signed up to its Very Important Trees campaign to try and ensure all Trees of National Special Interest have better long term protection from the threats posed by climate change, development, pests and diseases.
Peter Delow, chairman of the Cubbington Action Group against HS2, said: “I am asking people to vote for our treasured and much-loved pear tree in order to highlight its plight.
“It seems inconceivable to me that such an important specimen will be grubbed up to make way for HS2, but all of our efforts so far have been unable to save it from impending destruction.”
The Trust, with support from players of People’s Postcode Lottery, is now inviting the public to vote for their favourite tree before October 12.